Provectus News

Data Highlights Involvement of Immune System in Response to Provectus's PV-10 Therapy and Its Role in the Bystander Effect
Monday March 15, 2010
Intriguing Results Presented by Dr. Sanjiv Agarwala at Seventh International Symposium on Melanoma and Other Cutaneous Malignancies
Announces Plans to Conduct Research on Mechanism of Action

Provectus announced today that Dr. Sanjiv Agarwala, in his presentation at the Seventh International Symposium on Melanoma and Other Cutaneous Malignancies on March 12, 2010, commented on the involvement of the immune system in response to PV-10 therapy and its role in the "bystander effect" in treating metastatic melanoma. Dr. Agarwala's presentation, entitled "Chemoablation in Melanoma: An Update," was given in the session entitled "Unique Approaches to Melanoma Therapy."

Dr. Agarwala, Chief, Medical Oncology and Hematology at St. Luke's Hospital and Health Network in Bethlehem, PA, and Principal Investigator for Provectus's Phase 2 PV-10 trial site at St. Luke's, noted, "PV-10 is of particular interest to me as an oncologist because it appears to recruit immune cells to the ablation site, leading to the potential of a systemic benefit. Efficacy data from Phase 1 and from the current Phase 2 study demonstrate a close correlation between objective response in treated lesions and response in uninjected lesions. Survival data from both studies further support a conclusion that patients that respond well to PV-10 respond well overall."

Dr. Agarwala also discussed plans to conduct research into PV-10's immunologic mechanism of action. He said, "I look forward to seeing the results of this research so we can fully understand the potential PV-10 may have in treating not only melanoma, but also other indications in oncology."

The complete press release is available at Provectus' website at:
http://www.pvct.com/pressrelease.html?article=20100315.