CytoGenix, Inc. (CYGX)
Interview with:
Dr. Malcolm Skolnick, Chairman and CEO
Business News, Financial News, Stocks, Money & Investment Ideas, CEO Interview
and Information on their
products and services based on proprietary DNA expression technology, in pre-clinical development including, anti-herpes, anti-psoriasis and anti-inflammatory topical creams.

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CytoGenix - going after diseases that they can approach with a topical delivery such as herpes and the human papaloma virus that causes cervical cancer



Healthcare
Biotechnology
(CYGX-OTC)

CytoGenix, Inc.

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Dr. Malcolm Skolnick
Chairman and
Chief Executive Officer

Interview conducted by:
Lynn Fosse
Senior Editor

CEOCFOinterviews.com
October 2003

CytoGenix Inc. (OTC: CYGX) is a biopharmaceutical company that develops and markets innovative products and services based on its proprietary DNA expression technology. CytoGenix has products in pre-clinical development including, anti-herpes, anti-psoriasis and anti-inflammatory topical creams. The company owns a U.S. patent for its core DNA expression technology and has 40 international or U.S. pending patent applications. Dr. Malcolm Skolnick, Chairman and CEO of CytoGenix, commenting on how the Company selects which diseases to target tell us, “The delivery being an important consideration, we have chosen to go after diseases that we can approach with topical delivery; that is putting our formulations onto skin or into cells that are available. For example, herpes because it is a skin disease is a good target. The human papaloma virus, which causes cervical cancer, is also a good target because we can approach that with a topical application. The human RHINO virus, which causes colds, is also a good target because we can approach that topically as well, by using an aerosol spray into the mucosal passages. The anti-inflammatory that we are after is another topical target because it expresses itself in skin and various types of dermatitis, abrasions and burns. We have chosen targets that we know we can make our technology work, in conjunction with delivery that we know we can achieve.” “Our idea to demonstrate the science for a particular approach is very sound.” Offers Dr. Skolnick, when asked what differentiates the CytoGenix business model from other companies in its sector, “We will take that science through cell cultures, tissue cultures, animal trials and into clinical trials, and then work hard to find strategic partners who can take the product the rest of the way to market. We expect to be able to make our primary revenue through licensing our technology in specific fields. The other part of our model is to use our technology to do what is called “target validations”, that is we can identify genes and the proteins that they express. When down-regulating those genes, we can also identify the cell phenotypes that are different without the particular protein. We have developed a variant of the technology, which we call “screening library,” which allows us to screen for millions of different type sequences that can have an affect on cells. We have also done that in conjunction with a number of different approaches to see the affect on cells.” Dr. Skolnick demonstrating that under his leadership, the Company understands what it needs to do to succeed internationally states, “We want to make sure that if our products are made and sold, they are done so under the compliance of whatever country’s regulatory elements there are. Certainly, that is going to b true inside the United States, and certainly, we want that to be so in The People’s Republic of China or whatever other countries where we expect to continue business. It will not do for us to go to the FDA and then have a record to where we sold product without regulatory approval. The pressure to do that is enormous because we have seen enough positive results from the use of our preparation, that people are putting demands upon us.” Offering some thoughts on what investors should look for when considering CytoGenix, “People should not invest in our company unless they have the intent to put some effort into understanding our technology, and then they should follow the way we are developing scientifically.” Continues Dr. Skolnick, “I think if people do that, they will recognize that we have an enormously broad platform that is approachable. We have a business model that we think is beginning to work. We have been in business with this technology for about four years, which is a short time for most Biotechs. We think that in our next round of funding we will get enough money to get a couple of our formulations into clinical trials. If we do, we will see success in our licensing to larger corporations that will be able to take us the rest of the way through the FDA. I advise people to look at our track-record, and look at our future plans to see whether we keep our promises.”

With headquarters in Houston, Texas, the Company dedicated to developing biopharmaceutical compounds and services based on its proprietary gene regulating technology. CytoGenix’s controls U.S. and foreign patents for their technology that is effective in targeting and reducing gene expression and indicates that they can stop cell growth in lung, breast and cervical cancer cells by applying the company's proprietary ssDNA expression system (single-stranded DNA expression system) against target proteins.

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